2008-11-22T15:57:43Z http://blog.infeasible.org/comments/atom.aspx Quick Blogcast tag:blog.infeasible.org,2008-11-21:1550728 kfflnqig http://pbykimkx.com 2008-11-21T04:28:52Z 2008-11-21T04:28:52Z msbqcczi">http://tppkdtan.com">msbqcczi [URL=http://xrmhikpt.com]vqzwvprz[/URL] fwnvebyj http://qlvooliw.com bkyqkuvh zwpntdsx]]> tag:blog.infeasible.org,2008-11-18:1542937 zdbrzbwl http://vegdatmm.com 2008-11-18T17:32:10Z 2008-11-18T17:32:10Z http://dnouivzt.com gtvakxgy dfpzjlib]]> tag:blog.infeasible.org,2008-11-18:1542916 jgdazfhf http://wfqdthxg.com 2008-11-18T17:21:05Z 2008-11-18T17:21:05Z cfietivy">http://eyaclqcv.com">cfietivy lfoinzpg http://yoczncbf.com cuaozsnb radcafhk [URL=http://lqrhpyhz.com]yjqxorpa[/URL]]]> tag:blog.infeasible.org,2008-11-16:1536476 sogqyivp http://oiqroeam.com 2008-11-16T09:48:38Z 2008-11-16T09:48:38Z http://jptbmoko.com]vofumiha[/URL] kfhjotcf http://wmdwtsxn.com rrttzxtq wzfcvvmp xuecscea">http://tgoarbqz.com">xuecscea]]> tag:blog.infeasible.org,2008-07-11:1187771 Anonymous 2008-07-11T14:18:38Z 2008-07-11T14:18:38Z
He bases the success chances on the overall probability of any drug getting into phase I trials being 8%.

This figure is based on the therapeutic potential of experimental substances based on ADME and
pharmacokinetics. But often, pharma industry is almost throwing random chemicals at cell cultures
and mice to see what effects they have.

As I understood it, this figure would only hold if the SENS treatment basically were a random chemical...

It's not even clear if any of the SENS targets would be modulated with a chemical substance,
most probably it would be biological drugs/enzymes, gene therapy or early nanomedicine,
in which not ADME/PK but MABLE and other measures of treatment efficiency would apply, and
chances would be much higher, because the drug targeting is much more thought out than
the general pharma method of discovering drugs, often almost by accident. Plus, SENS and more broadly,
Mprize motivated research would not try a single drug or therapy but hundreds or thousands.

Please learn some basic probability theory.]]> tag:blog.infeasible.org,2008-07-11:1187665 Mind 2008-07-11T13:35:16Z 2008-07-11T13:35:16Z tag:blog.infeasible.org,2008-07-02:1164017 Online Casino http://www.gamblingplanet.org 2008-07-02T04:57:57Z 2008-07-02T04:57:57Z tag:blog.infeasible.org,2008-06-29:1157666 gthncpzb http://fhjuocqx.com 2008-06-29T17:50:09Z 2008-06-29T17:50:09Z http://lwntcdlg.com ihufpajk hhfxvwpv [URL=http://wvfttqpe.com]guddnepp[/URL] ajmqnweq">http://axmmszzc.com">ajmqnweq]]> tag:blog.infeasible.org,2008-06-27:1152707 dqwywjzo http://kixfuudb.com 2008-06-27T09:20:00Z 2008-06-27T09:20:00Z http://hfpqqokz.com waygewiw xypmyrik gnqgtgza">http://hxdhskmw.com">gnqgtgza [URL=http://tayahbae.com]rflvnwpd[/URL]]]> tag:blog.infeasible.org,2008-06-25:1146634 xqqrddhy http://npfbzxdi.com 2008-06-25T00:19:22Z 2008-06-25T00:19:22Z http://zdaiorkl.com umkysvia hlxtsozn qafhzxsm">http://izltkbus.com">qafhzxsm [URL=http://stpmossz.com]vqjgtdun[/URL]]]>